Web22 Oct 2024 · Abstract A catalytic enantioselective three-component Ugi reaction was developed. SPINOL-derived phosphoric acid with bulky 2,4,6-tricyclohexylphenyl groups at … Web22 Oct 2024 · Abstract A catalytic enantioselective three-component Ugi reaction was developed. SPINOL-derived phosphoric acid with bulky 2,4,6-tricyclohexylphenyl groups at the 6,6′ positions was found to be the best catalyst to afford α-amino amide derivatives in good to excellent yields (62% to 99%) and enantiocontrol (81% to >99% enantiomeric …
Molecules Free Full-Text Multi-Gram Synthesis of Enantiopure …
Web13 Apr 2024 · a, The classic four-component Ugi reaction assembles α-amino amides. To generate β - amino amides, ambiphilic ynamides are identified as the suitable two-carbon synthons. b, Structures of the ... Web20 Mar 2009 · A novel three-component, one-pot reaction between primary (S)-amino acid amides, aldehydes and isocyanides in the presence of acetic acid yielding substituted 2- (cyanomethylamino)-acetamides 4 in… Expand 19 A novel three-component one-pot reaction involving alkynes, urea or thiourea, and aldehydes. Shenlin Huang, Yuanjiang Pan, … cws 4002010
The Ugi three-component reaction and its variants
Web12 Nov 2024 · Ugi’s reaction combines a carboxylic acid, an amine, an isocyanide, and an aldehyde or ketone, to make an α -acylaminoamide. The prototypical Ugi multicomponent reaction is very important to construct biologically important molecules [ 38] and natural products bearing peptides, many heterocycles [ 39, 40, 41] and even macrocycles [ 42 ]. Web22 Mar 2024 · Multicomponent reactions (MCRs) are one pot process during which three or more substrates react in a single chemical step to yield a product that incorporates all of … Web18 Nov 2024 · The nitrilium ion trapping in classical Ugi four-component reaction (Ugi-4CR) falls on carboxylic acids, which are generally believed to play a dual role: (1) impart LUMO … cws 4012010