WebNov 15, 2024 · Parasites of the genus Plasmodium, the etiological agent of malaria, are transmitted through the bite of anopheline mosquitoes, which deposit sporozoites into the … WebAug 1, 2009 · Work with Plasmodium merozoites shows that they invade cells in distinct stages, beginning with initial reversible attachment followed by irreversible attachment and the formation of a tight junction through which the parasite moves forward into the cell (reviewed in ). Upon entry into the host cell, the junction is sealed off and the zoite is ...
Plasmodium translocon component EXP2 facilitates hepatocyte
WebJan 17, 2024 · Upon transmission to the human host, Plasmodium sporozoites exit the skin, are taken up by the blood stream, and then travel to the liver where they infect and significantly modify a single hepatocyte. Low infection rates within the liver have made proteomic studies of infected hepatocytes challenging, particularly in vivo, and existing … WebOct 4, 2024 · Here we show that Plasmodium berghei parasites infecting hepatic cells rely on the PVM transmembrane protein UIS3 to avoid elimination by host-cell-mediated autophagy. We found that UIS3 binds host LC3 through a non-canonical interaction with a specialized surface on LC3 where host proteins with essential functions during autophagy … specific heat capacity si units
A Role for Apical Membrane Antigen 1 during Invasion of …
WebJul 5, 2024 · The molecular mechanisms involved during sporozoite invasion of hepatocytes remain poorly understood. In previous studies, two receptors of the Hepatitis C virus (HCV), the tetraspanin CD81 and the Scavenger Receptor BI (SR-BI), were shown to play an important role during entry of Plasmodium sporozoites into hepatocytic cells. WebJul 18, 2016 · Sporozoite invasion of hepatocytes is triggered through a cascade of signalling events initiated by interaction between the circumsporozoite (CS) protein on the sporozoite surface and the highly … WebMar 1, 2004 · Plasmodium sporozoite invasion of host hepatocytes is an initial key step of infection by the malaria parasite. Sporozoites can enter hepatocytes via two distinct … specific heat capacity silicon