Web15 hours ago · CLEVELAND — At age 41, Jennifer Davis learned she had a very dangerous type of breast cancer. Triple negative — the kind that few treatments work against. … WebJun 18, 2024 · Discoidin domain receptor (DDR) is a collagen-activated receptor tyrosine kinase that plays critical roles in regulating essential cellular processes such as morphogenesis, differentiation, proliferation, adhesion, migration, invasion, and matrix remodeling. As a result, DDR dysregulation has been a …
Discoidin Domain Receptor 2: A New Target in Cancer
WebFeb 16, 2024 · The team found DDR2, a collagen receptor tyrosine kinase, is like the Pied Piper: It paves the road, coaxing breast cancer cells to spread, and stimulates signaling to increase cancer cell growth. The immunofluorescence image above shows breast cancer cells (green) aligned with mesenchymal stem cells (red) expressing DDR2 protein (white). WebOct 1, 2024 · These data suggest that tyrosine kinase-independent functions of DDR2 could explain failures of tyrosine kinase inhibitor treatment in metastatic breast cancer … the magician michael scott
DDR2 upregulation confers ferroptosis ... - Oncogene
WebSep 11, 2015 · Clinical analysis revealed that DDR2 is an independent prognostic marker for predicting overall survival and disease free survival of HCC patients. Overexpression of DDR2 is associated with p-DDR2 amplification. In vitro studies showed that DDR2 facilitates HCC cell invasion, migration and EMT via activating ERK2 and stabilizing SNAIL1. WebSep 1, 2024 · We have identified a novel pathway (the cell surface receptor tyrosine kinase discoidin domain receptor 2 (DDR2)) turned on in breast cancer cells and activated by tumor environmental signals (fibrillar collagen) that is critical for breast cancer metastasis. WebMay 5, 2013 · DDR2 is expressed in human invasive ductal breast cancers and correlates with nuclear SNAIL1, loss of E-cadherin and increased collagen. We performed … the magician michael scott audiobook