WebDec 2, 2024 · A protein-containing CMA-targeting motif is recognized by the cytosolic chaperone HSC70 (Chiang et al., 1989; Cuervo, 2011; Kirchner et al., 2024). The next step of the CMA pathway is the binding of the protein complex, a target protein and HSC70, to the cytosolic tail of lysosome-associated membrane protein type 2A (LAMP-2A) at the … WebOct 28, 2024 · Upon ligand binding, AhR dissociates from its chaperone complex and translocates into the nucleus, where it interacts with its partner the AhR nuclear translocator (ARNT). ... AhR is part of a cytosolic multiprotein complex with HSP90 and the SRC kinase (Enan & Matsumura, 1996; Rey-Barroso et al, 2013) (Fig 4A).
Unfolding the chaperone story Molecular Biology of the Cell
WebAdditional inactivation of the cytosolic RNA sensor MDA5 (melanoma differentiation-associated gene 5; ... (HMGA2) induces DNA nicks at the transcription start site, which are required by the histone chaperone FACT complex to incorporate nucleosomes containing the histone variant H2A.X. Further, phosphorylation of H2A.X at S139 ... WebJan 21, 2024 · The goal is to provide a comprehensive review on the functions of … example of a library budget
A cytosolic iron chaperone that delivers iron to ferritin - PMC
WebMay 17, 2024 · For instance, besides HLJ1, we found notably that cytosolic SSE1, an … WebJul 21, 2024 · Heat shock cognate 71-kDa protein (HSC70), a constitutively expressed molecular chaperon within the heat shock protein 70 family, plays crucial roles in maintaining cellular environmental homeostasis through implicating in a wide variety of physiological processes, such as ATP metabolism, protein folding and transporting, … WebChaperone-mediated autophagy (CMA) is a type of autophagy in which a chaperone-dependent selective mechanism delivers and degrades cellular components. It is a lysosome-based catabolic process that occurs to maintain cellular homeostasis by catabolic lysis of excess or superfluous soluble cytosolic proteins. example of algorithm in real life